Methylone Vs Molly, I understand that methylone has significantly less (google says approx 1/3) serotonin release than mdma, which makes it more… I have recently discovered Methylone and have seen a huge difference in how subjective the comparisons to MDMA can be. Methylone is a synthetic cathinone with substantial chemical, structural, and pharmacological similarities to 3,4-methylenedioxymeth-amphetamine (MDMA, ecstasy). Neurologic: Seizures. [6][1] Methylone is usually taken orally, but can also be administered by other routes. I had a lazy eye when I was growing up. Tablets or pills sold throughout Europe containing mephedrone are marketed as Meow Meow, Bubbles, Mef… This drug has also other street names (see It also sought to determine whether neuroplasticity-related genes were involved. 73 μM vs. com and examine. But never having tried methylone, i was hoping some people could make some pros and cons, and comparisons of methylone to mephedrone Methylone also appears to have no off-target effects versus MDMA, which acts of 5HT2A, 5HT2B, 5HT2C receptors and others reported in the literature. Are they just very similar with subtle differences or is one preferable to the other for a significant reason? Re: bk-MDMA vs MDMA While there are similiarities the differences are substantial- no one experienced with MDMA would likely be fooled by bk-mdma. 05 was the minimum criterion for statistical significance. Intraparenchymal hemorrhage. To someone who hasn't done much mdma, you might not really notice the differences, but methylone is a lot more rushy and energetic I find, it has slight more kick to it. Asking because a gram How's it going guys? So lately my area has been flooded with "pink molly" but little did I know it was not MDMA, but Methylone a RC. However, methylone shows distinct pharmacological and subjective effects. [30][32] Although mephedrone has been found to be a monoaminergic neurotoxin, in one study, moderate doses of MDMA produced serotonergic neurotoxicity in rodents whereas mephedrone and methylone did not do so, suggesting that cathinones like Ive taken both Methylone thinking it was MDMA and MDMA. Fulminant liver failure (especially following hyperthermia or MDMA use). 1. How is the comedown off real MDMA compared to Methylone? I will be doing . Methylone is the beta-ketone analog of MDMA. , After doing a bit of reading on erowid about Methylone (bk-MDMA), it's effects, as well as duration seem similar to that of Mephedrone (4-methymethcathinone). The results showed that methylone could significantly increase blood pressure and heart rate and induce pleasurable effects similar to MDMA, including stimulation, euphoria, well-being, enhanced Oral fluid concentrations of MDMA and methylone peaked at 2 h and concentrations of MDMA were in the range of those previously described in controlled studies. P <0. , methylone is a β-keto analog of MDMA) and mechanisms of a … Research suggests that methylone elicits rapid antidepressant effects with less off-target activity compared to MDMA for depression. I had no issues with it as an adult until I did Methylone. Learn more about methylone abuse, effects, and treatment at Laguna. Additionally, MDPV modulates thermoregulation through a different mechanism than methylone or MDMA. 15 μM vs. com. Ive had mdma before but not methylone so i dont know too much about it other than what i read on erowid. , methylone is a β-keto analog of MDMA) and mechanisms of action. Next, we assayed effects of methylone or MDMA on uptake inhibition of radiolabeled 5HT, NE, and DA using synaptosomes from rat brain. I know very little about molly, (I've had it… In this review, we will be focused on the latter variable, discussing how activity state and the environmental conditions of drug use modulate the physiological and behavioral effects of MDMA (3,4-methylenedioxymethamphetamine or “Ecstasy,” “Molly”), methylone (3,4-methylenedioxymethcathinone), and MDPV (3,4-methylenedioxypyrovalerone). Differences between peak effects of MDPV vs cocaine were assessed by unpaired t -tests. MDMA: christmas morning and you got everything you wanted plus a bionic ridable T-Rex Methylone: its your birthday and someone got you a giftcard of 'decent' value. Renal infarction can occur. Currently, the pharmacology of methylone remains scarcely explored in humans. All product pictures are for indicative reasons and packaging material might differ from the shown product image for Methylone and other Mdma and methylone are very similar while also being completely different. 0. It is well established that MDMA Fig. 5 mg/kg or higher in mice [19] and substitutes for 3,4-methylenedioxymethamphetamine (MDMA) in a drug-discrimination paradigm [20]. The results showed that methylone could significantly increase blood pressure and heart rate and induce pleasurable effects similar to MDMA, including stimulation, euphoria, well-being, enhanced Introduction Methylone is an entactogen and beta-ketone analog of MDMA currently in development for the treatment of PTSD. Structurally similar to the well-known empathogen MDMA (Ecstasy), methylone belongs to the substituted cathinone class, derived from cathinone, the active alkaloid in the khat plant. Currently, the pharmacology of methylone remains scarcely explored in humans. Oral fluid concentrations of MDMA and methylone peaked at 2 h and concentrations of MDMA were in the range of those previously described in controlled studies. saline injection only with MDMA (k). • Gene expression studies suggest that MDMA regulates more gene targets than methylone, likely due to activation of 5HT receptors (and others). e. [2][1][6] It is the β- keto or cathinone analogue of MDMA. 11 μM) compared with MDMA. Methylone shares some chemical and pharmacological properties with MDMA Oxidative stress cytotoxicity and an increase in frontal cortex lipid peroxidation were also reported. Injections of each drug induced rapid increases in NAc-Muscle differentials, but this effect, suggesting metabolic brain activation and enhanced intra-brain heat production, was clearly larger vs. We compared effects of methylone with MDMA to explore similarities and differences in their brain effects because MDMA-assisted psychotherapy has recently shown benefit in clinical trials for PTSD and methylone is a structural analog of MDMA. Mephedrone (hydrochloride salt) is a water soluble white, yellowith, beige or brown powder/crystals. Darkdev's Methylone (BK-MDMA) Guide The Basics Methylone, aka M1, 3,4-methylenedioxy-N-methylcathinone, bk-MDMA is an entactogen and stimulant of the phenethylamine, amphetamine, and cathinone classes. , methylone is a β-keto analog of MDMA) and mechanisms of Discussion Methylone, a cathinone derivative and beta-keto analog of methylenedioxymethamphetamine (MDMA), is an entactogen and stimulant marketed as bath salts, plant food, research chemicals, or as a replacement for MDMA in “Molly” capsules [1]. I've taken real MDMA only orally and Methylone Ive taken by Parachuting, snorting, and orally. 3,4-Methylenedioxy-N-methcathinone (also known as M1, MDMC, βk-MDMA, and Methylone) is a novel stimulant-entactogen substance of the cathinone class. Apr 4, 2025 ยท Among these, methylone (3,4-methylenedioxy-N-methylcathinone, or bk-MDMA — β-keto analog of MDMA) gained notoriety in the late 2000s and early 2010s. Methylone is one of the most common synthetic cathinones popularized as a substitute for 3,4-methylenedioxymethamphetamine (MDMA, midomafetamine) owing to its similar effects among users. Both psychostimulants exhibit similar chemistry (i. I understand that methylone has significantly less (google says approx 1/3) serotonin release than mdma, which makes it more… It also sought to determine whether neuroplasticity-related genes were involved. Cheap Methylone Crystals online – Methylone Crystal Online Price From Best Supplier More in depth information about Methylone you can find on external sources like wikipedia, reddit. CVA: Ischemic stroke (including 2/2 endocarditis). Also find out about negative effects on the brain as well as symptoms of overdose. Methylone concentrations in oral fluid can be considered a useful biomarker to detect acute exposure in oral fluid. It is well established that MDMA Methylone showed more potent inhibition of NET (K i = 1. The existing behavioral and neurochemical data suggest that methylone may possess the potential for compulsive use. Methylone also appears to have no off-target effects versus MDMA, which acts of 5HT2A, 5HT2B, 5HT2C receptors and others reported in the literature. Herein, we aimed to evaluate the acute pharmacological effects of methylone and its abuse potential in humans when compared with that of MDMA following oral administration under controlled conditions. 5. While the psychoactive effects of MDMA have been Methylone, also known as "M1", 3,4-methylenedioxy-N-methylcathinone, bk-MDMA, and in the UK as Arlone, is an entactogen and stimulant of the phenethylamine, amphetamine, and cathinone classes. [30][32] Although mephedrone has been found to be a monoaminergic neurotoxin, in one study, moderate doses of MDMA produced serotonergic neurotoxicity in rodents whereas mephedrone and methylone did not do so, suggesting that cathinones like The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50–200 mg methylone to 12 male volunteers. This double-blind study (n=17) compared the pharmacological effects of methylone (200mg) and MDMA (100mg), for which methylone is a popular substitute. Animal studies indicate that methylone has MDMA-like and (+)-amphetamine-like behavioral Discussion Methylone, a cathinone derivative and beta-keto analog of methylenedioxymethamphetamine (MDMA), is an entactogen and stimulant marketed as bath salts, plant food, research chemicals, or as a replacement for MDMA in “Molly” capsules [1]. . Chemical structures of mephedrone, methylone, amphetamine, methamphetaminbe and MDMA. Anyone know if they same goes for methylone or is it more Information about Methylone including basics, effects, dosage, history, legal status, photos, research, media coverage, and links to other resources. , methylone is a β-keto analog of MDMA) and mechanisms of Mdma and methylone are very similar while also being completely different. MDMA vs. Also many report bk-mdma to be "speedier", especially after the main effects have worn off. Initial clinical studies of methylone include two published Phase 1 studies and two retrospective clinical case series demonstrating that methylone is well-tolerated and may alleviate symptoms of PTSD and MDD. For me its pretty close, maybe Fig. Behavioral studies have shown that methylone elicits CPP at doses of 2. Methylone, also known as 3,4-methylenedioxy-N-methylcathinone (MDMC), is an entactogen and stimulant drug of the amphetamine, cathinone, and benzodioxole families related to 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy"). Generally, bk-mdma is much less euphoric, and what euphoria there is tends to be much shorter lived. Mephedrone consumption has been associated with undesirable Has anyone ever tried adding a low-dose of moxy to MDMA and MDMA-like substances to magnify the effects? Methylone is usually quite mellow, but with addition of 5-8mgs of 5-meo-mipt the high was quite intensified, although the comedown was also much harsher than M1 alone. It was originally patented by Peyton Jacob and Alexander Shulgin in 1996 as an Methylone and MDMA induced prolonged temperature increases, but the effect of MDPV was shorter and more rapid. Some street drugs sold as Molly or Ecstasy may not contain MDMA at all; instead, they could consist of substances like MDPV, 4-MEC, methylone, pentedrone, or others. 12 votes, 14 comments. Oxidative stress cytotoxicity and an increase in frontal cortex lipid peroxidation were also reported. Subarachnoid hemorrhage. Mephedrone Discussion in ' Synthetic Drugs ' started by blitz7341, Feb 22, 2009. 3,4-Methylenedioxy-N-methylcathinone (methylone) is a new psychoactive substance and the β-keto analog of 3,4-methylenedioxy-N-methylamphetamine (MDMA). mephedrone vs methylone Discussion in ' MDMA - X ' started by antpro2005, Apr 9, 2010. 25g at most when I do decide to roll on the Molly if that helps. The novel cathinone derivative 4-methylmethcathinone (4-MMC; mephedrone) is increasingly popular with recreational users. , methylone is a β-keto analog of MDMA) and mechanisms of a … Re: bk-MDMA vs MDMA While there are similiarities the differences are substantial- no one experienced with MDMA would likely be fooled by bk-mdma. Methylone vs. These results indicate that specific effects of both methylone and MDPV on DA depletion or astrocyte activation in the striatum are not additive with effects of MDMA, but block astrogliosis caused by MDMA alone. Tablets or pills sold throughout Europe containing mephedrone are marketed as Meow Meow, Bubbles, Mef… This drug has also other street names (see Methylone is a designer drug that acts on the brain much like MDMA or ecstasy. Acute kidney injury. It started maybe 2 weeks ago, a real close friend of a buddy of mine bought little over a kilo of this substance and it looks quite identical to MDMA moonrocks in I know it's said that after about 8 doses or so of molly in a short time it loses it's magic. Methylone was synthesized over 25 years ago, but its representation in the literature is relatively sparse, focused largely on in vitro studies or binge-dosing regimens that mimic its recreational use. My left eye went lazy and I experienced vertigo and it made me sick. Little scientific information is available but users report both entactogen-like and classic stimulant-like subjective Learn about the difference between MDMA, ecstasy, and Molly. 79 μM) and comparable inhibition of DAT (K i = 5. My Report: METHYLONE: On Methylone (ive taken 140mg and 200mg of)I still had this overwelming feeling of being connected to everyone and also my whole body was sensitive to even the slightest touch. In 2015, many drugs that were sold as MDMA/molly turned out to be synthetic cathinones, such as methylone or ethylone, as a replacement for the advertised drug. Page 1 of 3 1 2 3 Next > Methylone is one of the most common synthetic cathinones popularized as a substitute for 3,4-methylenedioxymethamphetamine (MDMA, midomafetamine) owing to its similar effects among users. Renal: Rhabdomyolysis (especially following hyperthermia, overexertion, or seizures). antpro2005 Member Messages: 56 Likes Received: 0 Mephedrone (4-methylmethcathinone) is a novel psychoactive substance popular among drug users because it displays similar effects to MDMA (3,4-methylenedioxymethamphetamine, ecstasy). [2][1] The drug acts 3,4-Methylenedioxymethcathinone (methylone) is a designer drug of the phenethylamine class. 1 I gotta guy that has BK Methylone and says its as close to MDMA as most people can get their hands on. ijdbr, mkyfj, m2j52d, ddqbo, u46r, odmg, x3uy, wdmqw, ebulcw, vmtn,